Pain Regulation and the Essential Role of CBD

Pain Regulation and the Essential Role of CBD

Pain is best defined as the body’s mechanism to signal itself about the process of injury. This process has evolved naturally in us to protect and notify the authority that something is wrong. Damage of a nerve leads to a muddling of the signaling system, and these abnormal signals in turns are interpreted as pain by the brain.

Nearly one-third of the world population is thought to be affected by chronic pain. This estimate is more than heart disease, diabetes, and cancer combined. Not only is this impact responsible for disturbances in daily routine but also cost the economy billions of dollars.

What are the Types of Pain?

The two main categories of pain are neuropathic pain and nociceptive pain.

Nociceptive Pain

The concept of nociceptive is more familiar to most of us. This most commonly results due to an injury like appendicitis, a broken bone or tissue damage. The typical description from patients usually is of throbbing, sharp or aching pain. Pain stemming from the internal organs is termed as visceral pain while the somatic pain mainly refers to the pain originating from structures like bones, skin or muscles.

Neuropathic Pain

Neuropathic pain comprises of both central and peripheral pain components. The idea behind this form of pain is that it does not necessarily come from an injury process rather than changed wiring of the nervous system resulting in the perception of normal signals as painful ones. Numerous factors can result in this form of pain which include infections, nutritional imbalances, toxins, autoimmunity, and addictions. The usual description by a patient is that of a burning sensation. However, it is possible to experience the feeling of the numbness along the area of the affected nerve.

How can CBD Help with Pain Relief?

The endocannabinoids acting on the cannabinoid receptors are present throughout the peripheral nervous system to the brain. When endogenous cannabinoid molecules bind with their receptors, their agonistic properties result in stimulation and release of neurotransmitter which signal the body about the pain. Antagonistic cannabinoids, on the other hand, when bind to these receptors results in an inhibitory response and block the release of neurotransmitter.

CBD is known for its antagonistic effects on these receptors modulating nociceptive thresholds. This in turns decreases the pro-inflammatory response decreasing the inflammatory response as well as the pain caused by the neuropathic conditions.

Cannabinoids such as CBD, therefore, are well-known for their analgesic effects implicating their use in certain pain and sleep disorders. CBD has shown promising results in the treatment and management of chronic pain. The clinical trials conducted to evaluate the roles of CBD in reducing the intensity of painful symptoms associated with a number of a disorder that has been specifically promising. This promising drug has also been evaluated for its use in treating cancer pain, postoperative pain and fibromyalgia pain and migraine and even the pain following an amputation.

The best part about using this drug for chronic pain relief is the subjects are less likely to become tolerant to the therapeutically necessary doses of the drug.

Author Bio

James Peter is completing his masters in pharmacology, and his research projects specifically employ the evaluation of cannabis and cannabis derivatives and their interaction with the human body. This in turns has led him to discover the best CBD cream for pain relief and other CBD products useful in the chronic pain relief.

Leave a Reply

Your email address will not be published. Required fields are marked *